Extrahepatic manifestations and HEV, the genotype matters
Horvatits et al.
Extrahepatic manifestations and viral hepatitis: a topic attracting the attention of hepatologists for more than 30 years. Hepatitis B and C virus infections have been associated with various extrahepatic diseases and in some of these phenomena a causal relationship has been proven.
Within the last two decades there was growing interest and awareness for hepatitis E virus (HEV) infections worldwide [1,2]. HEV genotype (GT) 3, the predominant GT in Europe and the USA, presents as zoonosis, mainly transmitted by infectious swine meat . In contrast GT 1 and 2 are mainly transmitted by contaminated drinking water in tropical developing countries. A special situation is the setting of GT 4. This is a tropical virus, but in contrast to GT 1 and 2 it is mainly transmitted by consumption of swine meat, as GT 3 [1,2].
EBioMedicine - Oct 01, 2018 36|C|Pages 3-4